Early exclusive enteral feeding in 30-33 weeks gestation infants: a randomized controlled trial
Paediatrics
Early exclusive enteral feeding in 30-33 weeks gestation infants: a randomized controlled trial
Paediatrics

Early exclusive enteral feeding in 30-33 weeks gestation infants: a randomized controlled trial

J Perinatol. 2025 Feb 2. doi: 10.1038/s41372-025-02217-0. Online ahead of print.

ABSTRACT

OBJECTIVE: To evaluate feasibility and efficacy of early exclusive enteral feeding (EEEF) in reducing time to achieve full enteral feeds.

METHODS: A pragmatic randomized controlled trial of infants born at 300/7-336/7 weeks gestation. Infants were randomly assigned to receive EEEF (60-80 mL/kg/day) or conventional feeding (20-30 mL/kg/day) with intravenous fluids after birth. Feed volumes were increased by 20-30 mL/kg/day. Primary outcome was time to reach full enteral feeds.

RESULTS: Seventy infants were enrolled. Infants in EEEF group achieved full feeds sooner [Mean difference (MD) -1.2 (95%CI -1.8, -0.7)], required fewer hours of parenteral nutrition [0 (IQR 0, 19) vs. 91 (IQR 48, 132) hours, P < 0.001], had less need for central venous access (11.4% vs. 37.1%, P = 0.01) and had shorter hospital stays [MD -6.6 (95%CI -12.9, -0.2) days].

CONCLUSION: Early exclusive enteral feeding in 300/7-336/7 weeks gestation infants is feasible and reduces time required to achieve full enteral feeds and length of hospital stay.

TRIAL REGISTRATION: ClinicalTrials.gov: NCT03708068.

PMID:39894877 | DOI:10.1038/s41372-025-02217-0