Cancer Rep (Hoboken). 2024 Oct;7(10):e70024. doi: 10.1002/cnr2.70024.
ABSTRACT
BACKGROUND: Acute myeloid leukemia (AML) is a heterogenous and complex blood cancer requiring aggressive treatment. Early identification and prediction of the complications following treatment is vital for effective disease management.
AIMS: We explored associations between plasma protein levels and fever- and infection-related complications in 26 AML patients during chemotherapy-induced neutropenia.
MATERIAL AND METHODS: Longitudinal plasma profiling was conducted using data-dependent mass spectrometry analysis.
RESULTS: Mass spectrometry-based plasma profiling data correlated well with laboratory parameters, including C-reactive protein, and revealed a broader inflammation protein network associated with fever- and infection-related complications.
DISCUSSION AND CONCLUSION: These data indicate the potential of longitudinal plasma profiling in AML patients for identifying and predicting complications that may aid in improved disease monitoring and treatment.
PMID:39441646 | DOI:10.1002/cnr2.70024
