Month: <span>December 2025</span>
Month: December 2025

OTMODE: An Optimal Transport Theory-Based Framework for Identifying Differential Features in Single-Cell Multi-Omics Data

Bioinformatics. 2025 Dec 3:btaf650. doi: 10.1093/bioinformatics/btaf650. Online ahead of print. ABSTRACT MOTIVATION: Single-cell technologies enable high-resolution cellular studies but face challenges in identifying differential features …

Utility of Peripheral Blood Testing for Detection and Surveillance of Clonal Hematopoiesis in Predisposed Individuals (CH-IPI)

Blood. 2025 Nov 10:blood.2024028042. doi: 10.1182/blood.2024028042. Online ahead of print. ABSTRACT We evaluated 108 pediatric patients with bone marrow failure and leukemia predisposition for presence …

Rare in Rare: Overlapping Clinical Features in a Patient With Both Gaucher Disease Type 1 and B4GALT-CDG: Expanding the Clinical Spectrum With a Novel Pathogenic Variant

Clin Genet. 2025 Dec 3. doi: 10.1111/cge.70119. Online ahead of print. ABSTRACT This case highlights the complexity of diagnosing dual rare metabolic diseases and the …

Prognostic utility of pre-biologic treatment correlates of childhood severe asthma exacerbation risk: Real world evidence

Pediatr Allergy Immunol. 2025 Dec;36(12):e70247. doi: 10.1111/pai.70247. ABSTRACT BACKGROUND: Biologics have been shown to substantially reduce the risk of severe asthma exacerbations (SAEs) among children …