Month: <span>December 2025</span>
Month: December 2025

A Comparative Analysis of Bivalirudin and Heparin for Extracorporeal Membrane Oxygenation in a Pediatric Cardiothoracic Intensive Care Unit

ASAIO J. 2025 Nov 11. doi: 10.1097/MAT.0000000000002598. Online ahead of print. ABSTRACT Unfractionated heparin has long been the conventional anticoagulant for pediatric mechanical circulatory support …

Emapalumab use in malignancy-associated hemophagocytic lymphohistiocytosis in the United States: The REAL-HLH study

Blood Adv. 2025 Dec 3:bloodadvances.2024013690. doi: 10.1182/bloodadvances.2024013690. Online ahead of print. ABSTRACT Malignancy-associated hemophagocytic lymphohistiocytosis (mHLH), a hyperinflammatory syndrome, has poor prognosis and no standard …

A Phase 3 study to assess the safety and immunogenicity of a quadrivalent meningococcal conjugate vaccine (MenACYW-TT) co-administered with routine pediatric vaccines in healthy infants in the USA and Puerto Rico

Hum Vaccin Immunother. 2025 Dec;21(1):2588874. doi: 10.1080/21645515.2025.2588874. Epub 2025 Dec 3. ABSTRACT A quadrivalent meningococcal tetanus toxoid-conjugate vaccine, MenACYW-TT, has been developed to provide protection …

Dysregulated alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor-CD74 signaling

Sci Transl Med. 2025 Dec 3;17(827):eadr2277. doi: 10.1126/scitranslmed.adr2277. Epub 2025 Dec 3. ABSTRACT Aberrant proteostasis in alveolar type 2 epithelial cells (AEC2s) contributes to idiopathic …