October 2025 - Page 205 of 205

RNA-mediated condensation of TFE3 oncofusions facilitates transcriptional hub formation to promote translocation renal cell carcinoma

John Joseph October 1, 2025 October 1, 2025

Nat Commun. 2025 Sep 30;16(1):8712. doi: 10.1038/s41467-025-63761-z. ABSTRACT Transcription factor E3 (TFE3) oncofusions are frequently detected in the Microphthalmia transcription factor (MiT) family translocation renal …

Paediatrics

Oxidative stress-induced intervertebral disc remodelling and elevated stiffness drive idiopathic scoliosis in preclinical models

John Joseph October 1, 2025 October 1, 2025

Nat Commun. 2025 Sep 30;16(1):8719. doi: 10.1038/s41467-025-63742-2. ABSTRACT Adolescent idiopathic scoliosis (AIS) is the most prevalent pediatric spine disorder, developing in the absence of obvious …