Sebetralstat: First Approval
Drugs. 2025 Sep 27. doi: 10.1007/s40265-025-02239-0. Online ahead of print. ABSTRACT Sebetralstat (EKTERLY®), an orally available plasma kallikrein inhibitor, is being developed by KalVista Pharmaceuticals …
Month: September 2025
Characterizing tuberculous meningitis in a South African pediatric cohort using GCxGC-TOFMS metabolomics
Med Microbiol Immunol. 2025 Sep 27;214(1):46. doi: 10.1007/s00430-025-00857-9. ABSTRACT The objective of this study was to characterize the metabolic profile of tuberculous meningitis (TBM) in …
Pathophysiological Mechanisms Fostering Developmental and Epileptic Encephalopathies (DEE): a Complex Interplay between Genetics, Inflammation and Neurodegeneration
Curr Neurol Neurosci Rep. 2025 Sep 27;25(1):65. doi: 10.1007/s11910-025-01453-3. ABSTRACT PURPOSE OF THE REVIEW: Preclinical and clinical evidence support the notion that in Developmental and …
Neurosurgical journals’ policies on artificial intelligence use in manuscript preparation and peer review
Neurosurg Rev. 2025 Sep 27;48(1):670. doi: 10.1007/s10143-025-03793-7. ABSTRACT As artificial intelligence (AI), particularly large language models (LLMs), continues to progress, its impact on academic publishing, …
Piceatannol improves autoimmune hepatitis by inhibiting the immune activities of T cells and macrophages through binding with c-Jun
Immunol Res. 2025 Sep 27;73(1):137. doi: 10.1007/s12026-025-09689-4. ABSTRACT Autoimmune hepatitis (AIH) is an immune-mediated liver disease that currently lacks viable drug treatment methods. This study …
Risk factors for developmental delays in small for gestational age children at age of 24-36 months
Eur Child Adolesc Psychiatry. 2025 Sep 27. doi: 10.1007/s00787-025-02855-x. Online ahead of print. ABSTRACT Long-term neurodevelopmental/socioemotional risks in small for gestational age (SGA) children lack …
In silico purification improves DNA methylation-based classification rates of pediatric low-grade gliomas
Acta Neuropathol. 2025 Sep 27;150(1):34. doi: 10.1007/s00401-025-02939-7. ABSTRACT DNA methylation-based classification using the Heidelberg Classifier is a state-of-the-art data-driven method for molecular diagnosis of central …
Parallel Increase in Childhood Anorexia Nervosa and Early Puberty During the COVID-19 Pandemic
Int J Eat Disord. 2025 Sep 27. doi: 10.1002/eat.24556. Online ahead of print. ABSTRACT OBJECTIVE: During the COVID-19 pandemic, an increase in anorexia nervosa (AN), …
Prediction of Non-Remission in a 5-Year Follow-Up of Borderline Personality Disorder in Adolescence
Personal Ment Health. 2025 Nov;19(4):e70041. doi: 10.1002/pmh.70041. ABSTRACT In a 5-year longitudinal follow-up study of adolescents (N = 97) treated for borderline personality disorder (BPD), …
Gender-differentiated pathways from childhood trauma to self-injury: rumination as a mediator in depressed adolescents
BMC Psychol. 2025 Sep 26;13(1):1057. doi: 10.1186/s40359-025-03440-2. ABSTRACT BACKGROUND: Amid the global escalation of adolescent depression and non-suicidal self-injury (NSSI), childhood trauma has been identified …