Month: <span>May 2025</span>
Month: May 2025

Disruption of BAG3-mediated BACE1 stabilization alleviates neuropathology and memory deficits in a mouse model of Alzheimer’s disease

Sci Adv. 2025 May 23;11(21):eadt7981. doi: 10.1126/sciadv.adt7981. Epub 2025 May 23. ABSTRACT β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is the rate-limiting enzyme for …

Single-cell profiling demonstrates the combined effect of wheeze phenotype and infant viral infection on airway epithelial development

Sci Adv. 2025 May 23;11(21):eadr9995. doi: 10.1126/sciadv.adr9995. Epub 2025 May 23. ABSTRACT The development of the airway epithelium in asthma is unclear. We characterized nasal …

Image-guided targeting of mitochondrial metabolism sensitizes pediatric malignant rhabdoid tumors to low-dose radiotherapy

Sci Adv. 2025 May 23;11(21):eadv2930. doi: 10.1126/sciadv.adv2930. Epub 2025 May 23. ABSTRACT Tumor hypoxia leads to radioresistance and markedly worse clinical outcomes for pediatric malignant …

Immune cell infiltration into brain tumor microenvironment is mediated by Rab27-regulated vascular wall integrity

Sci Adv. 2025 May 23;11(21):eadr6940. doi: 10.1126/sciadv.adr6940. Epub 2025 May 23. ABSTRACT Aggressive brain tumors often exhibit immunologically ‘cold’ microenvironment, where the vascular barrier impedes …

Large Language Models and Text Embeddings for Detecting Depression and Suicide in Patient Narratives

JAMA Netw Open. 2025 May 1;8(5):e2511922. doi: 10.1001/jamanetworkopen.2025.11922. ABSTRACT IMPORTANCE: Large language models (LLMs) and text-embedding models have shown potential in assessing mental health risks …

Factors influencing participation in home, school, and community settings by 6- to 9-year-old children born preterm: a qualitative descriptive study

Qual Life Res. 2025 May 23. doi: 10.1007/s11136-025-03993-0. Online ahead of print. ABSTRACT PURPOSE: There is no published information on preterm children’s activities and participation …

Everybody @ease – reaching Out To Vulnerable Subgroups of Young People with Mental Health Problems in the Netherlands: an Adaptation of the Standard @ease Working Method

Child Psychiatry Hum Dev. 2025 May 23. doi: 10.1007/s10578-025-01861-z. Online ahead of print. ABSTRACT Young people with mental health problems do not always receive appropriate …