Month: <span>May 2025</span>
Month: May 2025

ABCC2 as a novel covariate influencing oxcarbazepine pharmacokinetics in pediatric epilepsy: Insights from population modeling

Drug Metab Dispos. 2025 May 2;53(6):100090. doi: 10.1016/j.dmd.2025.100090. Online ahead of print. ABSTRACT This study set out to establish a population pharmacokinetic (PPK) model of …

Intravenous Dabigatran Provides Effective, Reversible Anticoagulation for Cardiopulmonary Bypass in a Sheep Model

Anesthesiology. 2025 May 27. doi: 10.1097/ALN.0000000000005580. Online ahead of print. ABSTRACT BACKGROUND: Heparin is the standard anticoagulant used during Cardiopulmonary Bypass (CPB). However, there are …

Postoperative radiotherapy in subtotally-resected recurrent WHO grade 1 meningiomas with intermediate-/high-risk molecular profiles

Neuro Oncol. 2025 May 27:noaf125. doi: 10.1093/neuonc/noaf125. Online ahead of print. ABSTRACT BACKGROUND: Meningiomas represent the most common primary intracranial tumors in adults, with WHO …

Differential Risk Profiles for Slipped Capital Femoral Epiphysis in Pediatric Patients: A Comparative Analysis of Normal and Elevated BMI Groups

J Am Acad Orthop Surg. 2025 May 22. doi: 10.5435/JAAOS-D-24-01298. Online ahead of print. ABSTRACT INTRODUCTION: Slipped capital femoral epiphysis (SCFE) is a common hip …

Azetukalner, a Novel KV7 Potassium Channel Opener, in Adults With Major Depressive Disorder: A Randomized Clinical Trial

JAMA Netw Open. 2025 May 1;8(5):e2514278. doi: 10.1001/jamanetworkopen.2025.14278. ABSTRACT IMPORTANCE: Available antidepressants provide inadequate therapeutic responses in many patients with major depressive disorder (MDD), highlighting …