Month: <span>May 2025</span>
Month: May 2025

Upregulation of miR-17-3p is associated with HbF in patients with β-thalassemia and induces γ-globin expression by targeting BCL11A

Orphanet J Rare Dis. 2025 May 30;20(1):260. doi: 10.1186/s13023-025-03806-0. ABSTRACT BACKGROUND: Large number of microRNAs (miRNAs) have been found to be dysregulated in β-thalassemia, but …

Ivabradine use in critical care: a systematic review and metanalysis of cardiogenic and septic shock patients

BMC Anesthesiol. 2025 May 30;25(1):276. doi: 10.1186/s12871-025-03121-y. ABSTRACT INTRODUCTION: In patients with acute illness, compensatory tachycardia initially serves to maintain adequate cardiac output, oxygen delivery …

Structure-function analysis of CNGA3-associated achromatopsia patient variants complements clinical genomics in pathogenicity determination

Orphanet J Rare Dis. 2025 May 30;20(1):261. doi: 10.1186/s13023-025-03792-3. ABSTRACT BACKGROUND: Achromatopsia is an autosomal recessive genetic disease, and 95% of achromatopsia patients carry pathogenic …

Chemically defined and xeno-free media enables the derivation of human extended pluripotent stem cell lines from discarded blastocysts with a high efficiency

Cell Biosci. 2025 May 30;15(1):72. doi: 10.1186/s13578-025-01410-0. NO ABSTRACT PMID:40448189 | DOI:10.1186/s13578-025-01410-0

Interpenetrating network hydrogel-loaded embryonic stem cell-derived endocardial cells improves cardiac function after myocardial infarction

J Transl Med. 2025 May 30;23(1):603. doi: 10.1186/s12967-025-06603-2. ABSTRACT BACKGROUND: With an in-depth understanding of cardiac cell differentiation, cell therapy derived from stem cells has …

SLIT3-mediated intratumoral crosstalk induces neuroblastoma differentiation via a spontaneous regression-like program

J Transl Med. 2025 May 30;23(1):598. doi: 10.1186/s12967-025-06621-0. ABSTRACT BACKGROUND: Neuroblastoma, the most common pediatric extracranial solid tumor, has heterogeneous clinical outcomes ranging from malignant …

Gamma -aminobutyric acid ameliorates neurological impairments in type 1 diabetes mellitus mice by regulating the “gut flora-LPS-TLR4-NF-ΚB” signalling Axis

Diabetol Metab Syndr. 2025 May 30;17(1):182. doi: 10.1186/s13098-025-01752-2. ABSTRACT This study examined the potential impact of gamma-aminobutyric acid (GABA) supplementation on the progression of type …

Prevalence of overweight and obesity and determinants associated with BMI Z-scores in Indigenous Yaqui schoolchildren from Sonora: a representative survey

Arch Public Health. 2025 May 30;83(1):140. doi: 10.1186/s13690-025-01636-x. ABSTRACT BACKGROUND: The study of overweight and obesity in schoolchildren is crucial for preventing future chronic diseases …