Month: <span>April 2025</span>
Month: April 2025

Systematic identification of disease-causing promoter and untranslated region variants in 8040 undiagnosed individuals with rare disease

Genome Med. 2025 Apr 14;17(1):40. doi: 10.1186/s13073-025-01464-2. ABSTRACT BACKGROUND: Both promoters and untranslated regions (UTRs) have critical regulatory roles, yet variants in these regions are …

KF1601, a dual inhibitor of BCR::ABL1 and FLT3, overcomes drug resistance in FLT3+ blast phase chronic myeloid leukemia

Mol Cancer. 2025 Apr 14;24(1):114. doi: 10.1186/s12943-025-02292-z. ABSTRACT Blast phase chronic myeloid leukemia (BP-CML) poses significant clinical challenges due to its drug resistance, resulting from …

Clinical effectiveness of drop-in mental health services in paediatric healthcare settings: a non-randomised multi-site study for children, young people and their families

BMC Health Serv Res. 2025 Apr 14;25(1):546. doi: 10.1186/s12913-025-12681-1. ABSTRACT BACKGROUND: Despite the high prevalence of mental health disorders in children and young people with …

Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

Genome Med. 2025 Apr 14;17(1):39. doi: 10.1186/s13073-025-01451-7. ABSTRACT BACKGROUND: DNA methylation (DNAm) is a developmentally dynamic epigenetic process; yet, most epigenome-wide association studies (EWAS) have …

Enhancing clinical faculties’ knowledge, attitudes, and performance in clinical supervision: a workplace-based faculty development program using proctor’s model

BMC Med Educ. 2025 Apr 14;25(1):529. doi: 10.1186/s12909-025-06769-9. ABSTRACT BACKGROUND: Clinical supervision is crucial for developing medical trainees’ independence. Faculty development programs can enhance faculty …