Month: <span>January 2025</span>
Month: January 2025

Mate-Pair Sequencing Enables Identification and Delineation of Balanced and Unbalanced Structural Variants in Prenatal Cytogenomic Diagnostics

Clin Chem. 2025 Jan 3;71(1):155-168. doi: 10.1093/clinchem/hvae146. ABSTRACT BACKGROUND: Mate-pair sequencing detects both balanced and unbalanced structural variants (SVs) and simultaneously informs in relation to …

Low-Pass Whole Genome Sequencing of Cell-Free DNA from Cerebrospinal Fluid: A Focus on Pediatric Central Nervous System Tumors

Clin Chem. 2025 Jan 3;71(1):87-96. doi: 10.1093/clinchem/hvae140. ABSTRACT BACKGROUND: Cell-free DNA (cfDNA) technology has allowed for cerebrospinal fluid (CSF), a previously underutilized biofluid, to be …

Integrative Assessment of Total and Intact HIV-1 Reservoir by a 5-Region Multiplexed Rainbow DNA Digital PCR Assay

Clin Chem. 2025 Jan 3;71(1):203-214. doi: 10.1093/clinchem/hvae192. ABSTRACT BACKGROUND: Persistent latent reservoirs of intact HIV-1 proviruses, capable of rebounding despite suppressive antiretroviral therapy (ART), hinder …

Psychometric properties of the Arabic version of the Young Schema Questionnaire Short Form-Version 3 (YSQ-S3)

Sci Rep. 2025 Jan 2;15(1):406. doi: 10.1038/s41598-024-83089-w. ABSTRACT It is well evidenced that Early Maladaptive Schemas (EMS) are important mental health determinants, particularly in adolescents …