Month: <span>January 2025</span>
Month: January 2025

Design, Synthesis and Anti-Inflammatory Evaluation of 3-Substituted 5-Amidobenzoate Derivatives as Novel P2Y14 Receptor Antagonists via Structure-Guided Molecular Hybridization

J Med Chem. 2025 Jan 29. doi: 10.1021/acs.jmedchem.4c01539. Online ahead of print. ABSTRACT The P2Y14R is activated by UDP and UDP glucose and is involved …

Can Surgery Be Proposed to Adolescent Idiopathic Scoliosis Patients With Structural Lumbar Curves Associated With Nonreducible Iliolumbar Angle?

J Pediatr Orthop. 2025 Jan 29. doi: 10.1097/BPO.0000000000002905. Online ahead of print. ABSTRACT BACKGROUND: Lower instrumented vertebra (LIV) selection for adolescent idiopathic scoliosis (AIS) with …

Noncoding variants and sulcal patterns in congenital heart disease: Machine learning to predict functional impact

iScience. 2024 Dec 28;28(2):111707. doi: 10.1016/j.isci.2024.111707. eCollection 2025 Feb 21. ABSTRACT Neurodevelopmental impairments associated with congenital heart disease (CHD) may arise from perturbations in brain …