Targeting Plasmodium falciparum IspD in the Methyl-d-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity
J Med Chem. 2024 Sep 20. doi: 10.1021/acs.jmedchem.4c00212. Online ahead of print. ABSTRACT The methyl-d-erythritol phosphate (MEP) pathway has emerged as an interesting target in …