Month: <span>June 2024</span>
Month: June 2024

Challenges and opportunities in neonatal sepsis management: insights from a survey among clinicians in 25 Sub-Saharan African countries

BMJ Paediatr Open. 2024 Jun 17;8(1):e002398. doi: 10.1136/bmjpo-2023-002398. ABSTRACT BACKGROUND: Neonatal sepsis (NS) is a global health issue, particularly in Sub-Saharan Africa, where it accounts …

Use of phosphotyrosine-containing peptides to target SH2 domains: Antagonist peptides of the Crk/CrkL-p130Cas axis

Methods Enzymol. 2024;698:301-342. doi: 10.1016/bs.mie.2024.04.013. Epub 2024 Apr 27. ABSTRACT Protein-protein interactions between SH2 domains and segments of proteins that include a post-translationally phosphorylated tyrosine …

Trauma in neonatal acute brain slices alters calcium and network dynamics and causes calpain-mediated cell death

eNeuro. 2024 Jun 17:ENEURO.0007-24.2024. doi: 10.1523/ENEURO.0007-24.2024. Online ahead of print. ABSTRACT Preparing acute brain slices produces trauma that mimics severe penetrating brain injury. In neonatal …

Predictive utility of ANCA positivity and antigen specificity in the assessment of kidney disease in paediatric-onset small vessel vasculitis

RMD Open. 2024 Jun 17;10(2):e004315. doi: 10.1136/rmdopen-2024-004315. ABSTRACT OBJECTIVES: The objective of this study is to evaluate whether anti-neutrophil cytoplasmic antibody (ANCA) seropositivity and antigen …

An evaluation of the national testing response during the COVID-19 pandemic in England: a multistage mixed-methods study protocol

BMJ Open. 2024 Jun 16;14(6):e077271. doi: 10.1136/bmjopen-2023-077271. ABSTRACT INTRODUCTION: In 2020, the UK government established a large-scale testing programme to rapidly identify individuals in England …