Month: <span>June 2024</span>
Month: June 2024

Development and Evaluation of Ontogeny Functions of the Major UDP-Glucuronosyltransferase Enzymes to Underwrite Physiologically Based Pharmacokinetic Modeling in Pediatric Populations

J Clin Pharmacol. 2024 Jun 19. doi: 10.1002/jcph.2484. Online ahead of print. ABSTRACT Uridine 5′-diphospho-glucuronosyltransferases (UGTs) demonstrate variable expression in the pediatric population. Thus, understanding …

Transcriptome analysis identifies an ASD-Like phenotype in oligodendrocytes and microglia from C58/J amygdala that is dependent on sex and sociability

Behav Brain Funct. 2024 Jun 19;20(1):14. doi: 10.1186/s12993-024-00240-3. ABSTRACT BACKGROUND: Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with higher incidence in males …

Nutritional interventions in children with acute lymphoblastic leukemia undergoing antineoplastic treatment: a systematic review

BMC Nutr. 2024 Jun 19;10(1):89. doi: 10.1186/s40795-024-00892-4. ABSTRACT BACKGROUND: A compromised nutritional status jeopardizes a positive prognosis in acute lymphoblastic leukemia (ALL) patients. In low- …

An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs

Genome Biol. 2024 Jun 19;25(1):161. doi: 10.1186/s13059-024-03309-4. ABSTRACT BACKGROUND: Neuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program …

Predictors for poor daily weight gain in preterm neonates exposed to different dose regimens of caffeine in ICU- a retrospective cohort study

BMC Pediatr. 2024 Jun 20;24(1):401. doi: 10.1186/s12887-024-04850-8. ABSTRACT BACKGROUND: With a wide therapeutic index, efficacy, ease of use, and other neuroprotective and respiratory benefits, caffeine …